Fátima de Lourdes Ochoa-González, Irma E. González-Curiel, Alberto R. Cervantes-Villagrana, Julio C. Fernández-Ruiz and Julio E. Castañeda-Delgado* Pages 318 - 331 ( 14 )
Diabetes is a chronic disease characterized by marked alterations in the metabolism of glucose and by high concentrations of glucose in the blood due to a decreased insulin production or resistance to the action of this hormone in peripheral tissues. The International Diabetes Federation estimates a global incidence of diabetes of about 10% in the adult population (20 - 79 years old), some 430 million cases reported worldwide in 2018. It is well documented that people with diabetes have a higher susceptibility to infectious diseases and therefore show higher morbidity and mortality compared to the non-diabetic population. Given that the innate immune response plays a fundamental role in protecting against invading pathogens through a myriad of humoral and cellular mechanisms, the present work makes a comprehensive review of the innate immune alterations in patients with type 2 diabetes mellitus (T2D) as well as a brief description of the molecular events leading or associated to such conditions. We show that in these patients a compromised innate immune response increases susceptibility to infections.
Innate response, phagocytosis, Type 2 Diabetes Mellitus, infection, antimicrobial peptide, innate immune cells.
Unidad de Investigacion Biomedica de Zacatecas, Instituto Mexicano del Seguro Social (IMSS), Zacatecas, Zac., Maestria en Ciencia y Tecnologia Quimica, Unidad Academica de Ciencias Quimicas, Universidad Autonoma de Zacatecas, Zacatecas, Maestria en Ciencia y Tecnologia Quimica, Unidad Academica de Ciencias Quimicas, Universidad Autonoma de Zacatecas, Zacatecas, Unidad de Investigacion Biomedica de Zacatecas, Instituto Mexicano del Seguro Social (IMSS), Zacatecas, Zac., Unidad de Investigacion Biomedica de Zacatecas, Instituto Mexicano del Seguro Social (IMSS), Zacatecas, Zac.