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Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques

[ Vol. 24 , Issue. 5 ]

Author(s):

Fatemeh Tavakoli, Sara Sadat Khatami, Fatemeh Momeni, Javid Azadbakht* and Faezeh Ghasemi*   Pages 605 - 623 ( 19 )

Abstract:


Cervical malignancy is known as one of the important cancers which is originated from cervix. This malignancy has been observed in women infected with papillomavirus who had regular oral contraceptives, multiple pregnancies, and sexual relations. Early and fast cervical cancer diagnosis is known as two important aspects of cervical cancer therapy. Several investigations indicated that early and fast detection of cervical cancer could be associated with better treatment process and increasing survival rate of patients with this malignancy. Imaging techniques are very important diagnosis tools that could be employed for diagnosis and following responses to therapy in various cervical cancer stages. Multiple lines of evidence indicated that utilization of imaging techniques is related to some limitations (i.e. high cost, and invasive effects). Hence, it seems that along with using imaging techniques, finding and developing new biomarkers could be useful in the diagnosis and treatment of subjects with cervical cancer. Taken together, many studies showed that a variety of biomarkers including, several proteins, mRNAs, microRNAs, exosomes and polymorphisms might be introduced as prognostic, diagnostic and therapeutic biomarkers in cervical cancer therapy. In this review article, we highlighted imaging techniques as well as novel biomarkers for the diagnosis of cervical cancer.

Keywords:

Cervical cancer, imaging techniques, diagnostic biomarkers, prognostic biomarkers, therapeutic biomarkers, risk factors.

Affiliation:

Department of Biotechnology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Department of Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Isfahan Research Committee of Multiple Sclerosis, Alzahra Research Institute, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Department of Radiology and Imaging, Kashan University of Medical Science, Kashan, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran



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