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Bio-Fe3O4 Magnetic Nanoparticles Promoted Green Synthesis of thioxo- 1,3-Oxazole Derivatives: Study of Antimicrobial and Antioxidant Activity


Maryam Ghazvini, Fatemeh Sheikholeslami-Farahani*, Naghmeh Faal Hamedani, Ashraf Sadat Shahvelayati and Zohreh Rostami   Pages 1 - 10 ( 10 )


Aims and Objective: In this work 1,3-oxazoles were generated using multicomponent reaction of α-bromo ketones, alkyl (aryl) isothiocyanates, sodium hydride and Fe3O4 MNPs in water at room temperature in good yields. The nanoparticles that is generated via biosynthesis method have potentially valuable in different purposes such as organic synthesis.

Materials and Methods: To study antioxidant ability of some synthesized thioxo-1,3-oxazoles, diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction testes are employed. Among studied thioxo-1,3-oxazoles, 4b have good power for radical trapping and reduction activity than to standard antioxidant such as BHT and TBHQ. In addition, the antimicrobial activity of some thioxo-1,3-oxazoles was studied employing the disk diffusion test on Gram-positive bacteria and Gram-negative bacteria. The results of disk diffusion test showed that compound 4a, 4b, 4d and 4f prevented the bacterial growth.

Results: Without employing catalyst, these reactions have low yield and busy mixture. The synthesis of compound 4a as sample reaction have alike yield in the presence of ZnO-NPs and Fe3O4 MNPs (entry 20 and entry 30) but removal of catalyst from the mixture of reaction after completing of reaction is comfortable in present of Fe3O4 MNPs. Structures of 4a–4i are confirmed by IR, 1H NMR, 13C NMR mass spectra.

Conclusion: The reaction of α-bromo ketones, isothiocyanate and sodium hydride in the presence of catalytic amount of Fe3O4 MNPs in water generate 1,3-oxazole derivatives in good yields. Some advantages of performing these reactions with present procedure are carrying out these reactions in water as green solvent and simple removal of catalyst.


2-thioxo-1, 3-oxazole, Orange peel extract, Fe3O4-MNPs, Alkyl (aryl) isothiocyanates, Alkyl bromides, antioxidant ability.


Department of Chemistry, Payame Noor University(PNU), P.O. Box: 19395-4697, Tehran, Department of Chemistry, Firoozkooh Branch, Islamic Azad University, Firoozkooh, Department of Chemistry, Faculty of Valiasr, Tehran Branch, Technical and Vocational University (TVU), Tehran, Department of Chemistry, Faculty of Science, Yadegar-e-Imam Khomeini (RAH), Shahre Rey Branch, Islamic Azad University, Tehran, Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr

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