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1,2,5-Thiadiazole Scaffold: A Review on Recent Progress in Biological Activities

Author(s):

Suraj N. Mali* and Anima Pandey*   Pages 1 - 17 ( 17 )

Abstract:


Background: Thiadiazoles can be considered as the privileged scaffold having diverse pharmacological potentials such as antihypertensive, anti-HIV, antimicrobials, antileishmanial agents, etc. In particular, 1,2,5-thiadiazoles and their fused analogues are subjects of fast-growing interest due to their higher significance in the fields of biomedicine and material sciences.

Objective: This study aims to collect detailed medicinal information about aspects of 1,2,5- thiadiazole.

Methods: A systemic search has been carried out using PubMed, Google Scholar, CNKI, etc., for relevant studies having the keyword, ‘1,2,5-thiadiazole’.

Results and Conclusion: In this mini-review, we have covered known procedures of the synthesis and explored in details all known advancements of this scaffold concerning to its biological activities.

Keywords:

Thiadiazoles, 1, 2, 5-thiadiazole, synthesis, biological activities, anthra[1, 2-c][1, 2, 5]thiadiazole-6, 11-dione, Chemistry.

Affiliation:

Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Jharkhand, Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Jharkhand



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