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Novel Drug Delivery System for Curcumin: Implementation to Improve Therapeutic Efficacy against Neurological Disorders

Author(s):

Roohi Mohi-ud-din*, Reyaz Hassan Mir, Taha Umair Wani, Abdul Jalil Shah, Ishtiyaq Mohi-Ud-Din, Mudasir Ahmad Dar and Faheem Hyder Pottoo*   Pages 1 - 9 ( 9 )

Abstract:


Background: Curcumin, a hydrophobic polyphenolic compound present in Curcuma longa Linn. (Turmeric), has been used to improve various neurodegenerative conditions, including Amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Prion disease, stroke, anxiety, depression, and ageing. However, the Blood-Brain Barrier (BBB) impedes the delivery of curcumin to the brain, limiting its therapeutic potential.

Objective/Aim: This review summarises the recent advances towards the therapeutic efficacy of curcumin along with various novel strategies to overcome its poor bioavailability across the bloodbrain barrier.

Methods: The data for the compilation of this review work were searched in PubMed Scopus, Google Scholar, and Science Direct.

Results: Various approaches have been opted to expedite the delivery of curcumin across the blood-brain barrier, including liposomes, micelles, polymeric nanoparticles, exosomes, dualtargeting nanoparticles, etc.

Conclusion: The review also summarises the numerous toxicological studies and the role of curcumin in CNS disorders.

Keywords:

Curcumin, neurodegenerative disease, therapeutic effect, drug delivery, nanomedicine, bioavailability.

Affiliation:

Pharmacognosy Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir, Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir, Pharmaceutics Division, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir , Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir, Faculty of Veterinary Sciences and Husbandry, SKAUST-K, Shuhama, Alusteng, J&K-190006, Pharmacognosy Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir, Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, 31441, Dammam



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