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Amelioration of Experimental Hepatotoxicity in Rats by Portulaca oleracea Linn. from Kashmir Himalaya

Author(s):

Mohd Akbar Dar*, Prince Ahad Mir, Mubashir Hussain Masoodi*, Ali S. Alqahtani, Nasir A. Siddiqui and Bahar Ahmad  

Abstract:


Background: Traditionally, Portulaca oleracea Linn for treating abscesses, dysentery, and also for the treatment of liver diseases. Recent studies have reported its efficacy as neuroprotective, analgesic and anti-inflammatory, a bronchodilator, anticancer, antioxidant, wound healing, besides other important pharmacological actions.

Aim and Objective: For curing liver diseases, Chinese use juice from the fresh leaves of Portulaca oleracea Linn, hence to prove this claim an in-vivo hepatoprotective study of extracts from Portulaca oleracea Linn. against carbon tetrachloride hepatotoxic rats.

Methods: The in-vitro antioxidant activity by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay and hepatoprotective activity of extracts of Portulaca oleracea Linn. was assessed against the carbon tetrachloride-induced toxicity rat model.

Results: The extracts of Portulaca oleracea Linn produced concentration-dependent percentage inhibition of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical and most significantly by methanol extract. Among the extracts, methanol extract showed a significant decrease in Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP) levels, and a significant increase in total protein (TP) levels against carbon tetrachloride-induced liver toxicity.

Conclusion: The results obtained showed that methanol extract of Portulaca oleracea Linn. possesses significant DPPH free radical scavenging and hepatoprotective potential.

Keywords:

Portulaca oleracea Linn., hepatoprotective, in-vitro antioxidant, 2, 2-diphenyl-1-picrylhydrazyl, carbon tetrachloride, silymarin.

Affiliation:

Natural Products Research Laboratory, Department of Pharmaceutical Sciences, School of Applied Sciences & Technology, University of Kashmir, Hazratbal Srinagar, J&K, Pharmacognosy and Phytochemistry Research Laboratory, Department of Pharmaceutical Sciences, School of Applied Sciences & Technology, University of Kashmir, Hazratbal Srinagar, J&K, Natural Products Research Laboratory, Department of Pharmaceutical Sciences, School of Applied Sciences & Technology, University of Kashmir, Hazratbal Srinagar, J&K, Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi



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