Ana Fernandez-Bustamante and John E. Repine Pages 1400 - 1408 ( 9 )
The Acute Respiratory Distress Syndrome (ARDS) is a highly fatal pro-inflammatory oxidative respiratory disease. Relatively recently, the modulating effects of chronic inflammatory processes on ARDS susceptibility have been recognized in a number of clinical studies. Herein, we briefly review some of the chronic conditions that have been reported to increase (cigarette smoking and alcohol abuse) or decrease (diabetes and obesity) susceptibility to ARDS. We also propose some potential pathways that may hold clues regarding the pathogenesis and/or therapy for ARDS.
ARDS, susceptibility, modulation, chronic inflammation.
, University of Colorado SOM, Dept. of Anesthesiology & Webb-Waring Center, 12631 E 17th Ave, AO-1, R2012, MS 8202, Aurora, CO, 80045, USA.