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A Highly Efficient Green Synthesis of N-Alkyl 2-[(2-Oxo-2-Aryl Ethyl) Amino] Benzamide Derivatives from Reaction of Isatoic Anhydride, Primary Amines and 2-Bromoacethophenone

[ Vol. 15 , Issue. 9 ]

Author(s):

Maryam Sabbaghan and Zinatossadat Hossaini   Pages 745 - 748 ( 4 )

Abstract:


N-alkyl 2-[(2-oxo-2-aryl ethyl)amino] benzamide derivatives have been synthesized in high yields. This involves three-component reaction of isatoic anhydride, primary amines in the presence of 2-bromoacethophenone derivatives. The reaction workup is simple and the products can be easily separated from the reaction mixture.

Keywords:

2-bromoacethophenone, Benzamide, green synthesis, one-pot synthesis, solvent-free, Isatoic Anhydride, Primary Amines, Diversity-oriented synthesis (DOS), heterocycles compound, pharmacological properties

Affiliation:

Chemistry Department, Faculty of Sciences, Shahid Rajaee Teacher Training University, P.O. Box 16785-163, Tehran, Iran.



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