Submit Manuscript  

Article Details

Cu(II) Schiff Base Complex as a Highly Efficient Catalyst for the Synthesis of Polyhydroquinoline Derivatives via Hantzsch Condensation in Water

[ Vol. 16 , Issue. 10 ]


Seyed Mohammad Vahdat   Pages 782 - 787 ( 6 )


In the present study, Cu(II) Schiff-base complex is introduced as a highly efficient and green solid catalyst for the unsymmetrical Hantzsch condensation through a four-component coupling of various aldehydes, dimedone, ethyl acetoacetate and ammonium acetate to form polyhydroquinoline derivatives in good to excellent yields. This reaction was carried out in the presence of 1 mol% of catalysts in water at room temperature. The reusability of the catalysts was demonstrated by a five-run test. Remarkable features of this new procedure are cleaner reaction profiles, shorter reactiontimes, simple experimental and work-up procedures.


Cu(II) schiff-base catalyst, hantzsch condensation, polyhydroquinoline, water solvent.


Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.

Read Full-Text article