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A Novel Three-Component Reaction for the Synthesis of 1,3-Benzoxazines in Water

[ Vol. 16 , Issue. 10 ]


Faramarz Rostami-Charati   Pages 840 - 844 ( 5 )


A simple and proficient method for the synthesis of 1,3-benzoxazine derivatives via three-component reaction of isocyanide and isoquinoline with 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone or 4-hydroxycumarine in water in the presence of piperidine at 70°C is reported.


1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, 1, 3-benzoxazine, Isocyanide, isoquinoline, threecomponent reaction.


Department of Chemistry, Facualty of Science, Gonbad Kavous University, P.O. Box 163, Gonbad, Iran.

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