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One-pot Synthesis of Dihydropyrano[2,3-c]chromenes via a Three-component Reaction in Aqueous Media

[ Vol. 16 , Issue. 10 ]


Saeed Balalaie, Ahmad Khazaie and Morteza Ashouriha   Pages 845 - 850 ( 6 )


An efficient protocol for the synthesis of dihydropyrano [2,3-c] chromenes derivatives by one-pot threecomponent reaction of aromatic aldehydes, malononitrile or methyl cyanoacetate, and 4-hydroxy coumarin has been developed using catalytic amount (10%) of three different catalysts piperidine, triethyl amine, and natrium carbonate in aqueous media. The present protocol has significant features such as easy set-up and work-up, environmentally benign, high yields, short reaction times.


Aqueous media, Dihydropyrano[2, 3-c]chromenes, Natrium carbonate, One-pot three-component reaction, Piperidine, Triethyl amine.


Peptide Chemistry Research Center, K. N. Toosi University of Technology, P. O. Box 15875-4416, Tehran, Iran.

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