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Fast and Green One-Pot Multicomponent Synthesis of a Library of Pyrrolo[1,2-c] Pyrimidines Under Microwave Irradiation

[ Vol. 16 , Issue. 10 ]


Emilian Georgescu, Florentina Georgescu, Constantin Draghici, Liliana Cristian, Marcel Mirel Popa and Florea Dumitrascu   Pages 851 - 857 ( 7 )


A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly.


1, 3-dipolar cycloaddition, microwaves, multicomponent reaction, N-ylide, pyrrolo[1, 2-c]pyrimidine.


Center for Organic Chemistry "C. D. Nenitzescu", Romanian Academy, Spl. Independentei 202B, Bucharest 060023, Romania.

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