Mina Dehghani-Samani, Naiemeh Hassanzadeh, Hamidreza Kabiri, Marzieh Jafari, Matineh Rahmani G. Shahrokhi, Maryam J. Chermahini, Arvand Akbari, Esmat Noshadi, Esmaeil Mahmoudi* and Amela Jusic* Pages 981 - 987 ( 7 )
Background and Objective: The SOX2OT lcnRNA has been recognized as a positive regulator in the transcription regulation of the SOX2 gene. Recent studies have approved the dysregulation of SOX2OT lncRNA expression patterns in some common cancer types, including esophageal, lung, and breast cancer. The objective of the present study was to investigate the correlation between overexpression of SOX2OT lcnRNA and susceptibility to breast cancer.
Methods: SOX2OT lncRNA expression profiling in 15 breast cancer and normal tumour-adjacent breast tissue samples was performed by using qRT-PCR. To evaluate the diagnostic potential of the SOX2OT lncRNA, we performed ROC curve analyses.
Results: The expression of SOX2OT lncRNA in patients suffering from breast cancer revealed a significant overexpression in comparison with the healthy group (P<0.001). Significantly, the elevated circulating SOX2OT lncRNA was found specific to breast cancer and could differentiate breast cancer from controls with 100% of both sensitivity and specificity. Based on the Kaplan- Meier analysis, there was no significant correlation between SOX2OT lcnRNA expression and overall survival.
Conclusion: The results confirmed the association between breast cancer and higher SOX2OT lncRNA expression. According to the ROC curve results, SOX2OT lcnRNA could be a new measurable indicator of the breast cancer and a potential therapeutic target for breast cancer patients.
Breast cancer, lcnRNA, SOX2OT, qRT-PCR, cancer, overexpression of SOX2OT.
Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Department of Biology, Tehran Medical Branch, Islamic Azad University, Tehran, Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Department of Medicine, Najafabad Branch, Islamic Azad University, Najafabad, Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Genetic Research Center, Shahrekord Branch, Islamic Azad University, Shahrekord, Department of Biology, Faculty of Science, Fars Science and Research Branch, Islamic Azad University, Marvdasht, Department of Biology, Faculty of Science, Fars Science and Research Branch, Islamic Azad University, Marvdasht, Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Faculty of Natural Sciences and Mathematics, Department of Biology, University of Tuzla, Tuzla