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On-line Sample Preparation for High Throughput Reversed-phase LC / MS Analysis of Combinatorial Chemistry Libraries.

[ Vol. 4 , Issue. 3 ]


Liang Tang, William. L. Fitch, Peter Smith, David Tumelty, Kathy Cao and Steven W. Ferla   Pages 287 - 293 ( 7 )


An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography / mass spectrometry (LC / MS). This approach is particularly helpful for the LC / MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.


High Throughput Reversed, Combinatorial Chemistry Libraries, liquid chromatography, Reversed Phase HPLC Columns, dioctyl phthalate, CTC syringe, TentaGel


Department of Pharmacology and Preclinical Development. 2 Corporate Drive, South San Francisco, CA 94080, USA.

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