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Solid-Phase Synthesis and Biological Screening of N-alpha-Mercaptoamide Template-Based Matrix Metalloprotease Inhibitors

[ Vol. 3 , Issue. 1 ]

Author(s):

J. F. Lynas, S. L. Martin, B. Walker, A. D. Baxter, J. Bird, R. Bhogal, J. G. Montana and D. A. Owen   Pages 37 - 41 ( 5 )

Abstract:


A series of N-alpha-mercaptoacetyl containing dipeptides have been prepared on solid-phase supports as putative matrix metalloprotease (MMP) inhibitors. Inhibitor design was based on a positional scanning approach of the amino acids present within a template molecule, previously shown to be an MMP inhibitor with good pharmacological characteristics. This study is the first step in a unique programme, designed to expand the repertoire of molecular templates which can be chosen as starting points for the development of more focused parallel and or combinatorial libraries of MMP inhibitors as a means to accelerate the lead discovery process. This paper reports the success of such an approach in the development of agents with activity against a number of pathologically important MMPs. After screening of these positional scanning libraries, we have obtained important SAR information, in particular, pharmacophores with the ability to impart selectivity for particular MMP species.

Keywords:

Solid phase synthesis, N alpha mercaptoamide template based, Matrix Metalloprotease inhibitors, MMP inhibitors, Mercaptoaetyl MMP inhibitors

Affiliation:

Division of Biomedicinal Chemistry, School of Pharmacy, Queens University Belfast, Medical Biology Centre, 79 Lisburn Road, Belfast BT9 7BL, Northern Ireland, U.K



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