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Recent Advances in Quality Control of Traditional Chinese Medicines

[ Vol. 13 , Issue. 10 ]

Author(s):

E-Hu Liu, Lian-Wen Qi, Kai Li, Chu Chu and Ping Li   Pages 869 - 884 ( 16 )

Abstract:


Traditional Chinese medicines (TCMs) have been used for disease prevention and therapy in China for a long history and are becoming increasingly popular over the world. However, TCMs are complex mixtures and contain usually hundreds of chemically different constituents, which make the quality control of crude drugs and their medical preparations extremely difficult. Therefore, better analytical strategies to assure their efficacy, safety and consistency are in great demand. The present work provides an overview of the development of quality control for TCMs based on microscopic and molecular identification, quantitative and qualitative analysis, fingerprint, combination of fingerprint and multi-component quantification, as well as activity-integrated fingerprint over the last five years. The biological fingerprinting analysis of TCMs with targeting absorption, distribution, metabolism, excretion by chromatographic and chemometric method are also highlighted due to its broad application in the quality control of TCMs. The comprehensive methods analyzed with modern hyphenated techniques are strongly recommended to assess the authenticity, quality consistency and stability of TCMs.

Keywords:

Quality control, quantitative and qualitative analysis, fingerprint, ADME studies, Traditional Chinese medicines, TCMs, Panax Ginseng, Oldenlandia diffusa, Caulis Sinomenii, Rhizoma Coptidis, Radix Sophorae Tonkinensis, Rhizoma Menispermi, Stephania tetrandra, sequence characterized amplified regions, SCAR, amplification refractory mutation system, ARMS, simple sequence repeat, SSR, Fritillaria pallidiflora, Drynaria fortunei, Cimicifuga foetida, Lonicera japonica, Dendrobium officinale, Eleutherococcus senticosus, ultraperformance liquid chromatography /mass spectrometry, UPLC-MS, rapid resolution liquid, chromatography (RRLC), Periploca forrestii, Schizonepeta tenuifolia, Foeniculum vulgare, Curcuma longa, Curcuma wenyujin, Schisandra chinensis, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Houttuynia cordata, Ligusticum chuanxiong, capillary zone electrophoresis, CZE, micellar electrokinetic chromatography, MEKC, non-aqueous CE, NACE, microemulsion electrokinetic chromatography, MEEKC, Thin-layer chromatography, biological response fingerprinting

Affiliation:

Key Laboratory of Modern Chinese Medicines (China Pharmaceutical University), Ministry of Education, No. 24 Tongjia Lane, Nanjing 210009, China.



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