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A Rapid, Four-Component Synthesis of Functionalized Thiazoles

[ Vol. 14 , Issue. 9 ]

Author(s):

Maryam Sabbaghan, Mostafa Alidoust and Zinatossadat Hossaini   Pages 824 - 828 ( 5 )

Abstract:


An efficient synthesis of 2-(dialkylamino)-4-phenyl)-1,3-thiazol-5-yl)(phenyl)methanone using acid chlorides, secondary amines, 2-bromoacethophenone and ammonium thiocyanate is described.

Keywords:

Thiazole, Hantzsch synthesis, 2-Bromoacethophenone, Aroyl isothiocyanate, Secondary amine, acid chlorides, heterocycle, estrogen receptors, fungicides, drugs

Affiliation:

Chemistry Department, Faculty of Sciences, Shahid Rajaee Teacher Training University, P.O. Box 16785-163, Tehran, Iran.



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