Zinatossadat Hossaini, Faramarz Rostami-Charati, Somayeh Firoziyan, Maryam Sabbaghan and Mohammad A. Khalilzadeh Pages 503 - 508 ( 6 )
An efficient synthesis of dialkyl pyrrolo[2,1-a]isoquinoline-2,3-dicarboxylates, pyrrolo[1,2-a]quinoline-1,2- dicarboxylates and indolizines is described via one-pot reactions of isoquinoline, quinoline or pyridine and phenacyl bromids with dialkyl acetylenedicarboxylates or diaryloylacetylene under solvent-free conditions at 50oC. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods.
Indolizine, isoquinoline, one-pot reactions, phenacyl bromides, solvent-free, synthesis, multicomponent reactions, NMR specturm, heterocyclic compounds, reactants
Department of Chemistry, Qaemshahr Branch, Islamic Azad University, P.O. Box 163, Qaemshahr, Iran.